apalutamide will lessen the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medications which might be CYP3A4 substrates can result in decreased publicity to those prescription drugs.The event of dihydrocodein